I have been using a dual-monitor setup for a couple of years now, and find it a very practial way to develop.
I also work from home, and use Remote Desktop (RDP) to connect back to my workstation at work. The problem is that RDP only works on a single screen - so when you launch Visual Studio, all the windows that were anchored on the second screen now are messed up.
The solution is to use the Import and Export Settings wizard to save two window layouts - one for a single screen and one for a dual screen. You can then load these settings to reset the window layout for the appropriate monitor.
To automate the process even further, you can create some Visual Studio Macros and assign them to a custom toolbar so that you can do it all with a single click of your mouse.
Here's my macro code that loads the two different window settings:
DTE.ExecuteCommand("Tools.ImportandExportSettings", "/import:""U:\My Documents\Visual Studio 2005\Settings\rdp.vssettings""")
DTE.ExecuteCommand("Tools.ImportandExportSettings", "/import:""U:\My Documents\Visual Studio 2005\Settings\dual monitor.vssettings""")